Comprehensive Flow Structures and Hemodynamic Analysis of Patient-Specific Cerebral Aneurysms using Volumetric PIV

ORAL

Abstract

Cerebrovascular hemodynamic factors are believed to play a role in progression and rupture of intracranial aneurysms (ICA). Computational fluid dynamics (CFD) has overwhelmingly been the modality used for hemodynamic ICA studies. Velocity fields obtained from 4D Flow MRI have been used but are limited by low resolution and dynamic range, hindering accurate hemodynamic analysis. Experimental particle image velocimetry (PIV) studies in this domain have been noticeably limited, and to-date only two-velocity component PIV studies have been reported. In this work, we present volumetric (3D-3 component) PIV results using two patient-specific cerebral aneurysm models. Subsequently, 3D hemodynamic metrics including wall shear stress (WSS), oscillatory shear index, residence times, pressure, and coherent and frequency structures were computed. Resulting flow metrics were compared to those obtained from CFD and MRI. Preliminary comparisons across modalities have revealed subtle differences between CFD and PIV data, e.g. in areas of low WSS, which may have high impact on aneurysm stability. The results demonstrate a need for more volumetric PIV studies in this domain.

*American Heart Association pre-doctoral fellowship (17PRE33670268) to Melissa Brindise is gratefully acknowledged.

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Presenters

  • Melissa Brindise

    • Purdue Univ
    • School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    • Purdue University

Authors

  • Melissa Brindise

    • Purdue Univ
    • School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    • Purdue University

  • Sean M Rothenberger

    • Purdue University
    • Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

  • Ben Dickerhoff

    • Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
    • Marquette University

  • Susanne Schnell

    • Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    • Northwestern University
    • Radiology, Northwestern University, Chicago, IL, United States

  • Michael Markl

    • Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    • Northwestern University
    • Radiology, Northwestern University, Chicago, IL, United States, Biomedical Engineering, Northwestern University, Chicago, IL, United States

  • David Saloner

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    • University of California San Francisco

  • Vitaliy L Rayz

    • Purdue University

  • Pavlos P Vlachos

    • School of Mechanical Engineering, Purdue University, West Lafayette, Indiana
    • Purdue University
    • Purdue Univ
    • School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    • Department of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    • Department of Mechanical Engineering, Purdue University