In-vitro experiments characterizing the cerebrospinal fluid flow in the central nervous system
ORAL
Abstract
The characterization of cerebrospinal fluid (CSF) pulsatile-flow dynamics in the central nervous system (CNS) is fundamental for the study of CSF-related disorders. Recently developed theoretical descriptions for the CSF flow in the spinal canal and in the cerebral aqueduct can be used in combination with MRI flow-rate measurements to determine intracranial pressure temporal fluctuations and interventricular pressure differences. These descriptions have been validated via in-vitro experiments involving anatomically correct models. For the spinal canal, an elastic silicone model with relevant material properties reflective of the spinal-canal wave dynamics have been developed. Preliminary results indicate good agreement with the models.
*This work was supported by the National Institute of Neurological Disorders and Stroke through contract No. 1R01NS120343-01 by the National Science Foundation through grant number 1853954, by the Spanish MICINN through grants PID2020-115961RB-C31 and PID2020-115961RB-C32, and by the Junta de Andalucia and European Funds through grant No. P18-FR-4619. F Moral-Pulido wants to thank the Spanish Ministry of Universities through grant No. FPU18/05694.
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Publication:Sincomb, Stephanie, et al (2022). "A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal"
Sincomb, Stephanie & Coenen, Wilfried & Gutiérrez-Montes, Cándido & Martínez-Bazán, C. & Haughton, Victor & Sánchez, A.L.. (2022). A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal. Journal of Fluid Mechanics. 939. 10.1017/jfm.2022.215.
