Cells Mechanotransduction: Geometrical Confinement for Cell Wave Control

Organisms develop from a single cell through a complicated procedure with multiple factors. One of the factors that decide a role of a cell in an organism is the spatial patterning of cell behavior. Cells travel in a mechanical wave like pattern with a certain wave length. We investigate the characteristics of the mechanical waves by confining tissues to a certain geometry that interferes with the wave length of the cell, manipulate the environment of the cell, then analyze the tissue reaction using Particle Image Velocimetry (PIV) and Traction Force Microscopy (TFM).