Selectivity of plasma treatment in in-vitro co-culture model

Cold physical plasmas are successfully used for medical therapy [1-3]. Recent plasma sources are certified for wound healing. Empirical observations in plasma-medicine, however, continue to lack precise fundamental understanding of the biochemical processes that lead to a successful plasma-based therapy. To make the new technology available to the fields of bone infection and cancer, we need to bridge the gap from fundamental research to clinical studies and applications with fast and reliable test platforms. Our platform allows us to study the interaction of exogeneous reactive oxygen and nitrogen species (RONS) supplied by cold plasma jet with a 3D printed bone tissue model. Controlling plasma reactivity and studying selectivity of plasma in a 3D model in a controlled environment enables us to selectively observe single pathways of cancer inactivation.