Lattice Model Investigations of Protein Aggregation

ORAL

Abstract

Protein aggregation is known to be important in a variety of diseases. We have expanded a well-known 3-dimensional protein folding computer lattice model with explicit side-chains in order to investigate the thermodynamics and statistical mechanics of protein aggregation between two chains. The modeling of a two-chain system presents technical and physics issues in addition to those found when modeling only a single chain. We report on preliminary results of the simulations.

–

Authors

  • Yanxin Liu

    Department of Physics, Florida International University, Miami, FL 33199

  • Prem Chapagain

    Department of Physicss, Florida International University, Department of Physics, Florida International University, Miami, FL 33199

  • Jose Parra

    Department of Physics, Florida International University, Miami, FL 33199

  • Bernard Gerstman

    Department of Physics, Florida International University, Miami, FL 33199, Department of Physics, Florida International University