Microfluidic bubble logic and applications

We present a novel all-fluidic logic family operating at low Reynolds numbers in newtonian fluids. A bubble in a microfluidic channel represnets a bit. Nonlinearities are introduced in an otherwise linear, reversible flow by bubble-bubble interactions. This allows us to simultaneously perform chemistry and process control without external control elements. A toggle flip-flop, AND/OR/NOT gates, ring oscillator and an electro-bubble modulator will be presented. Applications in high-throughput screening and combinatorial chemistry will be highlighted.