Hyperpolarized Long-\emph T$\bf_1$ Silicon Nanoparticles for Magnetic Resonance Imaging

ORAL

Abstract

Nanoparticles are currently being widely investigated as targetable contrast agents for magnetic resonance imaging (MRI). Silicon is a promising material system for use as a magnetic resonance imaging agent due to its long bulk (T$\bf_1$) times and receptivity to hyperpolarization. We present studies of the nuclear relaxation (T$\bf_1$) times of silicon nanoparticles as a function of particle size, dopant concentration and fabrication method. The T$\bf_1$ times of these particles are found to be remarkably long (depending on size and dopant concentration), allowing for them to be transported and administered on practical time scales. In addition, we discuss the particles' receptivity to hyperpolarization, via low temperature microwave induced dynamic nuclear polarization.

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Authors

  • Maja Cassidy

    SEAS, Harvard University, MA

  • Jacob Aptekar

    Department of Physics, Harvard University, MA

  • Alexander Johnson

    Department of Physics, Harvard University, MA

  • Robert Barton

    Department of Physics, Harvard University, MA

  • Menyoung Lee

    Department of Physics, Harvard University, MA

  • Alexander Ogier

    Department of Physics, Harvard University, MA

  • Chinh Vo

    Department of Physics, Harvard University, MA

  • Chandrasekhar Ramanathan

    Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, MIT, MA

  • David Cory

    Department of Nuclear Science and Engineering, MIT, MA

  • Alison Hill

    Harvard-Smithsonian CfA, MA

  • Ross Mair

    Harvard-Smithsonian CfA, MA

  • Matthew Rosen

    Harvard-Smithsonian CfA, MA

  • Ronald Walsworth

    Harvard-Smithsonian CfA, MA

  • Charles Marcus

    Harvard University, Department of Physics, Harvard University, MA