Characterization of Self-Forming Liposomes

We are currently using Raman spectroscopy to investigate thermodynamic phase transitions of self-forming liposomes, trademarked QuSomes {\texttrademark}. A Renishaw InVia Raman microscope system is used to acquire Raman spectra using a low-power argon ion laser (514.5 nm). A temperature-controlled sample holder is used to vary the temperature between -4 and 110\r{ }C. Spectral indications of phase transitions are seen. Techniques to examine mechanical properties of liposome formation, as well as size distribution and separation, are being developed. Preliminary data will be presented.