Templated Organization of Nanoparticles using Self-Assembling Peptides

ORAL

Abstract

Bottom up nanofabrication holds the potential for engineering matter at scales that are limit of current lithographic capability. Herein we describe the template-directed organization of inorganic nanoparticles into linear arrays using two distinct, hierarchically assembled peptide nanostructures. First, a long chain alanine-rich polypeptide was also used to create 1D nanoparticle assemblies. This peptide assembles into fibrils with monodisperse widths and presents charged functional groups in a desired periodic fashion along the length of the fibril. These functional groups bind nanoparticles that results in their spatially modulated linear arrangement. Second, a 20 amino acid peptide, consisting of alternating lysine and valine residues flanking a central diproline turn sequence (VKVKVKVKVPPTKVKVKVKV-NH2) was employed as a template for the organization of 2nm gold particles. This peptide self assembles into a laminated morphology in solution and has a periodic nanostructure. Negatively charged nanoparticles are templated into the positively charged lysine layer and are aligned within the laminated template to form laterally spaced (2D) linear arrays.

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Authors

  • Nikhil Sharma

    UDEL, University of Delaware, Department of Materials Science and Engineering University of Delaware

  • Joel Schneider

    University of Delaware, Department of Chemistry and Biochemistry, University of Delaware

  • Kristi Kiick

    University of Delaware

  • Darrin Pochan

    Department of Materials Science and Engineering and Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA, Materials Science and Engineering, University of Delaware, UDEL, Unviersity of Delaware, Department of Materials Science and Engineering University of Delaware, Department of Materials Science and Engineering and Delaware Biotechnology Institute, University of Delaware