Polymerization and oscillation stuttering in a filamentous model of the subcellular Min oscillation
ORAL
Abstract
We present a computational model of the {\em E. coli} Min oscillation that involves polymerization of MinD filaments followed by depolymerization stimulated by filament-end zones of MinE. Our stochastic model is fully three-dimensional, and tracks the diffusion and interactions of every MinD and MinE molecule. We recover self-organized Min oscillations. We investigate the experimental phenomenon of oscillation stuttering, which we relate to the disruption of MinE tip-binding at the filament scale.
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Authors
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Andrew Rutenberg
Dalhousie University
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Supratim Sengupta
Jawaharlal Nehru University
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Anirban Sain
Indian Institute of Technology - Bombay
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Julien Derr
Harvard University