Genearlized force-extension relation for DNA confined in sub-100nm nanoslits

ORAL

Abstract

We generalize the force-extension relation of DNA molecules confined in persistence length scale nanoslits. In strong confinement with slit geometry, the segmental correlation length of DNA molecules have two components -- in the confined and unconfined dimensions. In the confined dimension, the segmental correlation length is controlled by the slit height. In the unconfined dimension, the segmental correlation length increases as the slit height decreases. We characterize this effect, and generalize how this affects the entropic elasticity of confined DNA molecules. In addition, we investigate the structure of dense strongly confined semi-flexible polymers.

Authors

  • Yeng-Long Chen

    Institute of Physics and Research Center for Applied Sciences, Academia Sinica, Institute of Physics, Academia Sinica, Taipei Taiwan, Institude of Physics, Academia Sinica

  • Po-Keng Lin

    Institute of Physics and Research Center for Applied Sciences, Academia Sinica, Institute of Physics, Academia Sinica, Taipei Taiwan

  • Chia-Fu Chou

    Institute of Physics and Research Center for Applied Sciences, Academia Sinica, Academia Sinica, Institude of Physics, Academia Sinica