Electrohydrodynamics of DNA in confinement

ORAL

Abstract

New methods of DNA sequencing aim to exploit the direct reading of individual DNA molecules. Such methods require one be able to elongate DNA molecules so that individual base-pairs may be accessed. In turn, this requires a detailed understanding of the mechanical and thermodynamic behavior of DNA, so that external manipulation and confinement successfully stretch the molecule. We aim to study the interplay between electrostatic and hydrodynamic interactions on the conformations of coarse-grained DNA through use of computer simulations with the general geometry Ewald-like method (GGEM), both in bulk and under geometric confinement.

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Authors

  • Jonathan K. Whitmer

    Department of Chemical and Biological Engineering, University of Wisconsin--Madison, University of Wisconsin--Madison

  • Juan P. Hernandez-Ortiz

    Dept. of Materials, Universidad Nacional de Columbia

  • Juan J. de Pablo

    University of Wisconsin-Madison, Department of Chemical and Biological Engineering, University of Wisconsin--Madison, University of Wisconsin, Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA