Nanoscale Spin Resonance Spectroscopy by Diamond Sensor

Magnetic resonance (MR) spectroscopy, a powerful tool for the structure analysis of a molecule and widely used by chemists and biologists. However, conventional MR spectroscopy requires macroscopic sample quantities with typically a cubic sub-millimeters, i.e., nanoliter sized sample volume at least. Nano-MR has been a long-standing aspiration.To achieve the scientific goal, NV defect center in diamond - (NV) is selected as the sensitivity magnetic probe. Ultra-long spin coherence time for such qubits, even at room temperature, enables it is ultra-sensitivity to external magnetic noise with characteristic frequency.
We and co-workers successfully obtained the first single-protein spin resonance spectroscopy under ambient conditions [Science, 347, 1135 (2015)], realized atomic-scale structure analysis of single nuclear-spin clusters in diamond [Nature Physics, 10, 21 (2014)] and succeeded in detection of (5nm)³ hydrogen nuclear spin magnetic resonance spectroscopy [Science, 339, 561 (2013)]. In this talk, I will also introduce our new results, including mesoscopic EPR of optically polarized electron spins [arXiv: 1706.03939 (2017)], detection and imaging of bio-molecules in their native environment, and nuclear magnetic resonance of nanoscale water [arXiv: 1705.09201 (2017)].