Relaxation of self-induced jamming in confined budding yeast population
ORAL
Abstract
In nature, fast growing cells like microbes or cancer cells inevitably experience spatial confinement either due to living in a limited in space and/or because their population reaches high densities.
When grown in deformable micro-chambers that mimic these conditions, budding yeast cells displays features of jammed systems, as they build up large mechanical pressures resulting of heterogeneous forces inside the cell population. Such high pressure are sufficient to impact the population’s growth rate and eventually stall the cells, as individuals do not commit to division anymore (blocked in G1). We will present evidence that this phenotype is reversible if confinement is suddenly released and look at the relaxation process in terms of physical and physiological observables.
When grown in deformable micro-chambers that mimic these conditions, budding yeast cells displays features of jammed systems, as they build up large mechanical pressures resulting of heterogeneous forces inside the cell population. Such high pressure are sufficient to impact the population’s growth rate and eventually stall the cells, as individuals do not commit to division anymore (blocked in G1). We will present evidence that this phenotype is reversible if confinement is suddenly released and look at the relaxation process in terms of physical and physiological observables.
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Presenters
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Marie-Cécilia Duvernoy
University of California, Berkeley, Physics and Integrative Biology, University of California, Berkeley
Authors
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Marie-Cécilia Duvernoy
University of California, Berkeley, Physics and Integrative Biology, University of California, Berkeley
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Pawel Gniewek
University of California, Berkeley
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Carl Schreck
University of California, Berkeley, Univ of California - Berkeley
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Oskar Hallatschek
Physics and Integrative Biology, UC Berkeley, University of California, Berkeley, Physics and Integrative Biology, Univ of California - Berkeley, Physics, Integrative Biology, Univ of California - Berkeley, Physics and Integrative Biology, University of California, Berkeley, Univ of California - Berkeley