Physical modeling of cancer and immune cells in melanoma tumors

ORAL

Abstract

The emergence of two-photon imaging in live tissue allows us to study cell dynamics in three spatial dimensions over time. I will present quantitative image analysis of tumor and immune cells in live murine melanoma tumors. I will discuss how the structural and mechanical properties of cells impact the development and spatiotemporal evolution of melanoma tumors. The in vivo measurements will be compared to computational models of static packings of deformable polyhedra. In the simulations, we will study the cell shape, packing fraction, and mobility in response to applied forces as a function of the cell deformability. My talk will describe the advantages of physical modeling in understanding tumor formation and how the physical models can advance cancer diagnosis and treatment.

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Presenters

  • Alexandra Signoriello

    Computational Biology & Bioinformatics, Yale University

Authors

  • Alexandra Signoriello

    Computational Biology & Bioinformatics, Yale University

  • Armand Boroman

    Mechanical Engineering & Materials Science, Yale University, Mechanical Engineering and Material Sciences, Yale University

  • Marcus Bosenberg

    Dermatopathology, Yale University

  • Corey O'Hern

    Yale University, Mechanical Engineering & Materials Science, Yal University, Mechanical Engineering & Materials Science, Yale Univ, Mechanical Engineering & Materials Science, Yale University, Chemistry, Yale Univ, Department of Physics, Yale University

  • Mark Shattuck

    The City College of New York, Physics, City College of New York, City College of New York CUNY, Benjamin Levich Institute, CUNY, Benjamin Levich Institute and Physics Department, The City College of New York