Active process driven glass to fluid transition in growing tumor
ORAL
Abstract
<!--StartFragment-->We study the dynamics of collection of cancer cells driven by the mechanical interactions as well as division and death of cells using stochastic quantization method. Theory predicts caging effect depending on the strength of adhesion leading to glassy-phase in finite time and birth-death driven fluidization of colony of cells characterized by super-diffusive motion of cells in the long time scale. The theory can be applied to any systems involving division and death characterized by absence of fluctuation-dissipation theorem (FDT). From this unified theory based on stochastic quantization scheme, we understand the similarity between the predictions of super-diffusive motions of soap bubbles, CD$8^+$ T cells and tumor cells. The non-trivial exponent calculated by the theory is in excellent agreement with the exponents obtained by simulations of all three problems indicating all three problems belong to same universality class characterized by the same dynamical exponent in the long time limit.<!--EndFragment-->
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Presenters
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Himadri Samanta
Chemistry, University of Texas, Austin
Authors
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Himadri Samanta
Chemistry, University of Texas, Austin