Sperm motility in modulated microchannels

Sperm cells swim through the fluid by a periodic wave-like beating of their flagellum [1-3]. At low Reynolds numbers and in confinement, the directed motion of sperm and other microswimmers is strongly influenced by steric and hydrodynamic surface interactions [1]. We model sperm motility in mesoscale hydrodynamics simulations by imposing a planar traveling bending wave along the flagellum [2]. Sperm are simulated swimming in curved, straight, shallow and zigzag-shaped microchannels. Changes in the sidewall modulations and the imposed beat pattern allow the identification of a strong dependence of the surface attraction on the beat-shape envelope of the sperm cell. The simulations reveal a strong dependence of the deflection angle on the orientation of the beat plane with respect to the channel sidewall, and thus deepen the understanding of sperm navigation under strong confinement. Detachment of sperm, while swimming along curved walls, is dominated by either the emergence of a nonplanar component of the flagellar beat with increasing wavelength or the strong confinement in shallow channels.

[1] J. Elgeti et al., Rep. Prog. Phys. 78, 056601 (2015) [2] J. Elgeti et al., Biophys. J. 99, 1018 (2010) [3] G. Saggiorato et al., Nat. Commun. 8, 1415 (2017)