Self-assembly of Designed Nanoarchitectures via Shape and DNA-programmability

Creating complex nanoscale structures from simple building blocks is a well-recognized challenge. In this work, we show that a simple hollow square-bucket DNA frame can be used as a basic building block to prescribe self-assembly of one-dimensional(1D), two-dimensional (2D) and three-dimensional (3D) scaffolds, whose symmetry is only determined by DNA frame geometry. Due to the empty space of hollow square frame, these 1D, 2D and 3D scaffolds can be further utilized to host guest nano-objects such as nanoparticles via sequence-specified binding. We demonstrate a variety of linear architectures, such as the homo-chain-like, alternating-chain-like nanoparticles structures, and chiral organizations. We apply the developed method for generating 2D and 3D lattices with prescribed particle organizations.