X-ray Photon Correlation Spectroscopy Measurements of Protein Diffusion in Concentrated Alpha Crystallin Suspensions

ORAL

Abstract

The dynamics of concentrated suspensions of the crystallin eye-lens protein alpha crystallin was measured using x-ray photon correlation spectroscopy. For pure alpha crystallin suspensions the diffusive dynamics near the peak in the hard sphere structure are well described by a polydisperse hard sphere model. The intermediate scattering factor can be described by a stretched exponential function, and the concentration dependence of the relaxation time agrees with predictions from Langevin dynamics simulations.

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Presenters

  • Laurence Lurio

    Physics, Northern Illinois University

Authors

  • Laurence Lurio

    Physics, Northern Illinois University

  • Preeti Vodnala

    Physics, Northern Illinois University

  • Vidanage Nuwan C Karunaratne

    Northern Illinois University

  • George Thurston

    School of Physics and Astronomy, Rochester Institute of Technology, Rochester Institute of Technology, Physics, Rochester Institute of Technology

  • Michael Vega

    Chemistry and Biochemistry, Northern Illinois University

  • Elizabeth Gaillard

    Chemistry and Biochemistry, Northern Illinois University

  • Suresh Narayanan

    Argonne, Argonne National Laboratory

  • Alec Russell Sandy

    Argonne National Laboratory

  • Qingteng Zhang

    Argonne National Laboratory

  • Eric Dufresne

    Argonne National Laboratory

  • Giuseppe Foffi

    Laboratoire de Physique des Solides,, Universite Paris-Saclay

  • Pawel Grybos

    AGH University of Science and Technology,

  • Piotr Kmon

    AGH University of Science and Technology,

  • Piotr Maj

    AGH University of Science and Technology,

  • Robert Szczygiel

    AGH University of Science and Technology,