Multiscale Modeling of DNA Translocation through Multiple Nanopores

We report preliminary results for a multiscale modeling scheme to decipher signals recorded for a translocating DNA through a series of nanopores. We propose to relate the time series of the cross-correlation current from different pores calculated from ab initio studies [1] to the velocity correlation obtained by carrying out Brownian dynamics simulation on a coarse-grained (CG) model of a DNA as well as the nano-pores [2]. By suitable choices of different pore-poymer interactions we propose to relate the results obtained from a simple CG model to more refined but computationaly expensive models.


[1] Towfiq Ahmed, Jason T Haraldsen, John J Rehr, Massimiliano Di Ventra, Ivan Schuller and Alexander V Balatsky, Nanotechnology 25, 125705 (2014).
[2] Kaifu Luo, Tapio Ala-Nissila, See-Chen Ying, and Aniket Bhattacharya, Phys. Rev Lett. 100, 058101 (2008).