Mechanical feedback maintains polarization in budding yeast mating projection growth

Cell Polarization is one of the commonly studied cases of spontaneous symmetry breaking in cells and controls many cellular processes, including morphogenesis, in budding yeast. However, the mechanisms that coordinate continued polarization to the growth region during mating projection formation, and the subsequent change in geometry from a spherical cell, remain unknown. We theoretically show that a genetically-encoded mechanical feedback relaying information about cell’s geometry is sufficient to maintain key polarity molecules and growth machinery remain localized to the site of growth. We have demonstrated that this same feedback mechanism also results in cell wall stability.