Cellulose-Based Photonic Nanoparticles for Biomedical Imaging

Here we present a fluorescent targeting nanoparticle contrast agent that can serve as an effective companion solution for biomedical imaging and diagnostics of cancer. Particles can be used to label intra- and extracellular biomarkers and provide key information for clinical decisions based on high resolution, real-time optical imaging while mitigating off-target immunogenic effects. We utilize cellulose acetate to develop a class of benign, natural, and chemically inert fluorescent nanoparticles possessing well-defined safety profiles. Particles are generated from supramolecular assemblies of cellulose acetate and guest polymers, producing composite materials with good biocompatibility, tunable morphology, physical encapsulation ability, and excellent luminescence. We demonstrate effective in vivo targeting of sub-mm tumors in zebrafish cervical cancer xenografts as well as topical targeting of colon cancer tumors in mice. We expect a topically administered contrast agent can provide great clinical value especially in the realm of colorectal endoscopies.