Effect of cell softness and polydispersity on the viscosity of non-confluent tissue
ORAL
Abstract
The collective motion of cells in a tissue depends on the mechanical properties of the individual
cells. The stiffness of the cells and the size dispersity are crucial to determining the fate of the
tissue dynamics as they are directly related to the motility of each cell. Using agent(particle)-
based simulations of three-dimensional tissue, we showed that depending on the cell elasticity and
the size dispersity, the tissue exhibits fluid-like, glass-like, and glass-like dynamics followed by a
viscosity saturation. Furthermore, for a low value of polydispersity, the tissue crystallizes. In order
to visualize this complex behavior, we draw a phase diagram in the polydispersity-cell elasticity
plane.
cells. The stiffness of the cells and the size dispersity are crucial to determining the fate of the
tissue dynamics as they are directly related to the motility of each cell. Using agent(particle)-
based simulations of three-dimensional tissue, we showed that depending on the cell elasticity and
the size dispersity, the tissue exhibits fluid-like, glass-like, and glass-like dynamics followed by a
viscosity saturation. Furthermore, for a low value of polydispersity, the tissue crystallizes. In order
to visualize this complex behavior, we draw a phase diagram in the polydispersity-cell elasticity
plane.
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Presenters
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Rajsekhar Das
University of Texas at Austin
Authors
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Rajsekhar Das
University of Texas at Austin
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Xin Li
The university of Texas at Austin
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Sumit Sinha
Harvard University
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Devarajan Thirumalai
University of Texas at Austin, Department of Chemistry and Physics, The University of Texas at Austin, Austin 78712, UT Austin