Effects of Lipids during Insertion Process of pH Low Insertion Peptide into Membrane

Membrane system consists of two phases separated by the interfacial region. These two regions are hydrophobic lipid tail region and hydrophilic lipid head plus aqueous region. The interfacial attributes such as surface tension and elastic properties are particularly important while we deal with membrane-peptide association and integrations. Pressure profile plays the key role on determining such properties of the bilayer. The elastic properties of chains of lipid tail affects the entropy of the system. Inclusion and insertion of hydrophobic peptide into a membrane stiffen the lipid chains in its immediate vicinity. Therefore, peptide inclusion into a membrane lowers the conformation entropy of the system. This talk aims to focus on lipid effects to the free energy cost for insertion of pH Low Insertion Peptide into membrane.