Genome Organization & Subnuclear Phenomena II: Structural Dynamics to Gene Regulation

Presentations

• Computational approaches to dissect the multi-scale chromatin landscape and gene regulation

  ORAL · Invited

  March 7, 2024, 12:30 PM – March 7, 2024, 1:06 PM

  Presenters

  • Chongzhi Zang

    University of Virginia

  Authors

  • Chongzhi Zang

    University of Virginia

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• Geometric properties of Deinococcus radiodurans cells and nucleoids reflect effects of radiation exposure or the deletion of key genome-associated proteins

  ORAL

  March 7, 2024, 1:06 PM – March 7, 2024, 1:18 PM

  Publication: A manuscript is in preparation for Applied and Environmental Microbiology.

  Presenters

  • Vernita Gordon

    University of Texas at Austin

  Authors

  • Vernita Gordon

    University of Texas at Austin

  • Antonio Cordova

    University of Texas at Austin

  • Brandon Niese

    University of Texas at Austin

  • Philip Sweet

    University of Texas at Austin

  • Lydia Contreras

    University of Texas at Austin

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• Design principles of 3D epigenetic memory systems

  ORAL

  March 7, 2024, 1:18 PM – March 7, 2024, 1:30 PM

  Publication: J. A. Owen, D. Osmanovic, L. Mirny. Design principles of 3D epigenetic memory systems. Science (accepted)
  Preprint: https://www.biorxiv.org/content/10.1101/2022.09.24.509332v1
  
  

  Presenters

  • Jeremy A Owen

    Princeton University

  Authors

  • Jeremy A Owen

    Princeton University

  • Dino Osmanovic

    UCLA

  • Leonid A Mirny

    Massachusetts Institute of Technology MIT

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• Landscapes of Genomic Architecture Across Evolution

  ORAL

  March 7, 2024, 1:30 PM – March 7, 2024, 1:42 PM

  Presenters

  • Michele Di Pierro

    Northeastern University

  Authors

  • Michele Di Pierro

    Northeastern University

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• Model of Euchromatin Clustering Resulting from Local Nucleosome Interactions

  ORAL

  March 7, 2024, 1:42 PM – March 7, 2024, 1:54 PM

  Presenters

  • Joseph Wakim

    Stanford University

  Authors

  • Joseph Wakim

    Stanford University

  • Andrew Spakowitz

    Stanford University

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• Chromatin configurational dynamics in live cells reveals insights into gene localization within nucleus

  ORAL

  March 7, 2024, 1:54 PM – March 7, 2024, 2:06 PM

  Presenters

  • Andrew I Rodriguez

    Yale University

  Authors

  • Andrew I Rodriguez

    Yale University

  • Ivan Surovtsev

    Yale University

  • Megan C King

    Yale University

  • Simon G Mochrie

    Yale University

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• Distinct Material States of Interphase Chromatin in Normal and Cancer Cells Revealed by CRISPR Live-cell Imaging

  ORAL

  March 7, 2024, 2:06 PM – March 7, 2024, 2:18 PM

  Publication: [1] Ma et al. "CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging" Nature methods 15 (11), 928-931.
  [2] Chung et al. "Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation" Journal of Cell Science 136 (4), jcs260137.
  

  Presenters

  • Yu-Chieh Chung

    The Ohio State University

  Authors

  • Yu-Chieh Chung

    The Ohio State University

  • Li-Chun Tu

    The Ohio State University

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• Polymer model predicts epigenetic memory and heterogenous dynamics of constitutive heterochromatin domains

  ORAL

  March 7, 2024, 2:18 PM – March 7, 2024, 2:30 PM

  Presenters

  • Ramin Basir

    University of Pennsylvania

  Authors

  • Ramin Basir

    University of Pennsylvania

  • Vinayak Vinayak

    University of Pennsylvania

  • Vivek B Shenoy

    University of Pennsylvania

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• Force Spectroscopy on Tetranucleosomes Using DNA Origami Nanocalipers

  ORAL

  March 7, 2024, 2:30 PM – March 7, 2024, 2:42 PM

  Publication: Darcy M, Crocker K, Wang Y, Le JV Mohammadiroozbahani G, Abdelhamid MAS, Craggs TD, Castro CE, Bundschuh R, Poirier MG*. High Force Application by a Nanoscale DNA Force Spectrometer. ACS Nano 2022. Apr 6;16(4):5682-5695. doi: 10.1021/acsnano.1c10698.​
  ​
  Wang Y, Le JV, Crocker K, Darcy MA, Halley PD, Zhao D, Andrioff N, Croy C, Poirier MG, Bundschuh R, Castro CE. A nanoscale DNA force spectrometer capable of applying tension and compression on biomolecules. Nucleic Acids Res. 2021 Sep 7;49(15):8987-8999. doi: 10.1093/nar/gkab656.​
  ​
  Le JV, Luo Y, Darcy MA, Lucas CR, Goodwin MF, Poirier MG, Castro CE. Probing Nucleosome Stability with a DNA Origami Nanocaliper. ACS Nano 2016 Jul 26;10(7):7073-84.

  Presenters

  • Kalven R Bonin

    Ohio State University

  Authors

  • Kalven R Bonin

    Ohio State University

  • Yuchen Wang

    The Ohio State University

  • Ralf Bundschuh

    Ohio State University

  • Carlos E Castro

    Ohio State Univ - Columbus

  • Michael G Poirier

    Ohio State Univ - Columbus

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• Effects of chromatin phase separation on the morphology of eukaryotic cell nucleus

  ORAL

  March 7, 2024, 2:42 PM – March 7, 2024, 2:54 PM

  Presenters

  • Aykut Erbas

    Bilkent University UNAM

  Authors

  • Aykut Erbas

    Bilkent University UNAM

  • A Goktug Attar

    Bilkent University

  • Edward J Banigan

    Massachusetts Institute of Technology

  • Jaroslaw Paturej

    University of Silesia in Katowice

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• Unravelling the mechanism of HP1 eviction from methylated Histone H3: A DFT study suggests a complex salt bridge as the spurring interaction

  ORAL

  March 7, 2024, 2:54 PM – March 7, 2024, 3:06 PM

  Publication: G. Papamokos* E. Kaxiras* How to evict HP1 from H3: Using a double salt bridge Biophysical Chemistry 300, 107062, 2023

  Presenters

  • Georgios Papamokos

    Harvard University

  Authors

  • Georgios Papamokos

    Harvard University

  • Efthimios Kaxiras

    Harvard University

  View abstract →