Biomolecular Condensates II - Dynamics, Properties, Design

Presentations

• A physics-based model for predicting temperature-dependent phase behavior of proteins

  ORAL

  March 8, 2024, 9:00 AM – March 8, 2024, 9:12 AM

  Presenters

  • Ananya Chakravarti

    Princeton University

  Authors

  • Ananya Chakravarti

    Princeton University

  • Jerelle Joseph

    Princeton University

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• Investigating the molecular driving forces of liquid-liquid phase separation in intrinsically disordered proteins

  ORAL

  March 8, 2024, 9:12 AM – March 8, 2024, 9:24 AM

  Presenters

  • Ellen Carrick

    University of Bristol

  Authors

  • Ellen Carrick

    University of Bristol

  • Jennifer J McManus

    University of Bristol

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• Modeling phase separation of proteins with compact native states using LatticePy, a package for MCMC simulations on lattices

  ORAL

  March 8, 2024, 9:24 AM – March 8, 2024, 9:36 AM

  Publication: Weiner BG, Pyo AGT, Meir Y, Wingreen NS (2021) Motif-pattern dependence of biomolecular phase separation driven by specific interactions. PLoS Comput Biol 17(12): e1009748. https://doi.org/10.1371/journal.pcbi.1009748

  Presenters

  • Sohit Miglani

    Princeton University

  Authors

  • Sohit Miglani

    Princeton University

  • Ned S Wingreen

    Princeton University

  • Benjamin Weiner

    The Rockefeller University

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• Multiscale approaches to model the functions of Ubiquitin and SUMO modifications in protein phase separation

  ORAL

  March 8, 2024, 9:36 AM – March 8, 2024, 9:48 AM

  Publication: Planned paper:
  Multiscale approaches to model the functions of Ubiquitin and SUMO modifications in protein phase separation

  Presenters

  • Supriyo Naskar

    Max Planck Institute for Polymer Research

  Authors

  • Supriyo Naskar

    Max Planck Institute for Polymer Research

  • Kurt Kremer

    Max Planck Institute for Polymer Research

  • Oleksandra Kukharenko

    Max Planck Institute for Polymer Research

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• Thermodynamics and Transport Properties of Pure RNA condensates

  ORAL

  March 8, 2024, 9:48 AM – March 8, 2024, 10:00 AM

  Presenters

  • Dilimulati Aierken

    Princeton University

  Authors

  • Dilimulati Aierken

    Princeton University

  • Jerelle Joseph

    Princeton University

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• RNA-driven Percolation Transitions in Biomolecular Condensates

  ORAL

  March 8, 2024, 10:00 AM – March 8, 2024, 10:12 AM

  Publication: Mahendran, T.S., Wadsworth, G. M., Singh, A., Banerjee, P. R.*, 2023. RNA-driven Percolation Transitions in Aging Biomolecular Condensates. Manuscript Under Preparation.

  Presenters

  • Tharun Selvam Mahendran

    State University of New York at Buffalo, Department of Biology

  Authors

  • Tharun Selvam Mahendran

    State University of New York at Buffalo, Department of Biology

  • Gable Wadsworth

    State University of New York at Buffalo, Department of Physics

  • Anurag Singh

    University at Buffalo, The State University of New York, State University of New York at Buffalo, Department of Physics

  • Priya R Banerjee

    State Univ of NY - Buffalo, State University of New York at Buffalo, Department of Physics

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• Active remodeling of RNA interactions facilitates nonequilibrium steady states of protein-RNA condensates

  ORAL

  March 8, 2024, 10:12 AM – March 8, 2024, 10:24 AM

  Presenters

  • Sebastian T Coupe

    Massachusetts Institute of Technology

  Authors

  • Sebastian T Coupe

    Massachusetts Institute of Technology

  • Nikta Fakhri

    Massachusetts Institute of Technology

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• Modulating condensate properties and catalytic activity with peptide sequence in coacervate dispersions

  ORAL

  March 8, 2024, 10:24 AM – March 8, 2024, 10:36 AM

  Presenters

  • Patrick M McCall

    Leibniz Institute for Polymer Research Dresden

  Authors

  • Patrick M McCall

    Leibniz Institute for Polymer Research Dresden

  • Basusree Ghosh

    Max Planck Institute of Molecular Cell Biology and Genetics

  • Lars Hubatsch

    Max Planck Institute of Molecular Cell Biology and Genetics

  • T-Y Dora Tang

    Max Planck Institute of Molecular Cell Biology and Genetics

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• Functional membraneless organelles formed by de novo proteins

  ORAL

  March 8, 2024, 10:36 AM – March 8, 2024, 10:48 AM

  Publication: A. T. Hilditch, A. Romanyuk, Stephen J. Cross, R. Obexer*, J.J. McManus*, D. N. Woolfon*, Assembling membraneless organelles from de novo designed proteins, Nature Chemistry, DOI: 10.1038/s41557-023-01321-y (2023).

  Presenters

  • Jennifer J McManus

    University of Bristol

  Authors

  • Jennifer J McManus

    University of Bristol

  • Alexander T Hilditch

    University of Bristol

  • Andrey Romanyuk

    University of Bristol

  • Ragesh Kumar Thelakkadan Puthiyaveettil

    University of Bristol

  • Stephen J Cross

    University of Bristol

  • Richard Obexer

    University of Manchester

  • Derek N Woolfson

    University of Bristol

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• Synchronization of chemical reactions in a population of phase-separated droplets

  ORAL

  March 8, 2024, 10:48 AM – March 8, 2024, 11:00 AM

  Presenters

  • Alisdair Stevenson

    ETH Zurich

  Authors

  • Alisdair Stevenson

    ETH Zurich

  • Sudarshana Laha

    Max Planck Institute for Physics of Complex Systems

  • Christoph A Weber

    University of Augsburg

  • Thomas Michaels

    ETH Zurich, ETH Zürich

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• Diffusiophoresis promotes phase separation and transport of biomolecular condensates

  ORAL

  March 8, 2024, 11:00 AM – March 8, 2024, 11:12 AM

  Publication: Diffusiophoresis promotes phase separation and transport of biomolecular condensates.
  Viet Sang Doan, Ibraheem Alshareedah, Anurag Singh, Priya R. Banerjee, Sangwoo Shin
  bioRxiv 2023.07.03.547532; doi: https://doi.org/10.1101/2023.07.03.547532

  Presenters

  • Sangwoo Shin

    University at Buffalo, The State University of New York

  Authors

  • Viet Sang Doan

    University at Buffalo, The State University of New York

  • Ibraheem Alshareedah

    State Univ of NY - Buffalo

  • Anurag Singh

    University at Buffalo, The State University of New York, State University of New York at Buffalo, Department of Physics

  • Priya R Banerjee

    State Univ of NY - Buffalo, State University of New York at Buffalo, Department of Physics

  • Sangwoo Shin

    University at Buffalo, The State University of New York

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• Buffering of biomolecular condensate volume and mass in multi-component mixtures.

  ORAL

  March 8, 2024, 11:12 AM – March 8, 2024, 11:24 AM

  Publication: This work forms the basis of a planned paper.

  Presenters

  • Logan S de Monchaux-Irons

    ETH Zurich

  Authors

  • Logan S de Monchaux-Irons

    ETH Zurich

  • Thomas Michaels

    ETH Zurich, ETH Zürich

  • Nina Han

    ETH Zurich

  • Benjamin Frühbauer

    ETH Zurich

  • Leonidas Emmanouilidis

    ETH Zurich

  • Madhav Jagannathan

    ETH Zurich

  • Frederic Allain

    ETH Zurich

  • Giulia L Celora

    UCL, University College London

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• Physical Mechanisms of Protofilament Formation

  ORAL

  March 8, 2024, 11:24 AM – March 8, 2024, 11:36 AM

  Publication: "Physical mechanisms of protofilament formation" - to be submitted

  Presenters

  • Ioana M Ilie

    University of Amsterdam

  Authors

  • Ioana M Ilie

    University of Amsterdam

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• Developing methods to classify protein clusters as liquid-liquid phase separated biomolecular condensates in vivo.

  ORAL

  March 8, 2024, 11:36 AM – March 8, 2024, 11:48 AM

  Presenters

  • Alex Verbeem

    McMaster University

  Authors

  • Alex Verbeem

    McMaster University

  • Lydia Hodgins

    McGill University

  • Cécile Fradin

    McMaster University

  View abstract →