Driven Transport of DNA and Rod-like fd Viruses in Solid-State Nanopores

In this talk, I will describe the brief history of this field, which started out as a brave suggestion by John Kasianowicz and co-workers that one may be able to determine genetic sequence of nucleic acids using electrical signals of a nanopore, and the current understanding of physical processes (which are more complicated than originally thought) involved in driven transport in nanopores.~ I will describe some ongoing experiments using DNA and rod-like fd viruses as model systems. Finally I will discuss the feasibility of building a solid-state device mimicking polymerases using solid-state nanopores.