The Effect of \textit{Trans} Unsaturation on Molecular Organization in a Phospholipid Membrane

POSTER

Abstract

The ingestion of \textit{trans} fatty acids (TFA) formed during the partial hydrogenation of vegetable oils has been linked to a detrimental impact on health by an, as yet, unknown mechanism. We synthesized deuterated analogs of 1-elaidoyl-2-stearoylphosphatidylcholine ($t$18:1-18:0PC) that contains a single ``unnatural'' \textit{trans} double bond and 1-oleoyl-2-stearoylphosphatidylcholine ($c$18:1-18:0PC) that contains a single ``natural'' \textit{cis} double bond. Solid state $^{2}$H NMR spectra for model membranes prepared from these phospholipids reveal a higher chain melting temperature for the \textit{trans} isomer, indicating tighter molecular packing in the gel state. In the liquid crystalline, however, the difference between the \textit{trans} and \textit{cis }isomers is subtle. Order as probed by the perdeuterated [$^{2}$H$_{31}$]18:0 \textit{sn}-2 chain, and corroborated by molecular dynamics (MD) simulation, coincides within $<$5{\%}.

Authors

  • Smita Soni

    IUPUI1

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center

  • Anthony Colaprete

    Triumf, Texas A\&M University, Tel Aviv University, TRIUMF, Simon Fraser University, Dept. of Physics, SFU, BC, Canada, Department of Physics and Astronomy, University of British Columbia, Cavendish Laboratory, University of Cambridge, Department of Physics, Simon Fraser University, University of British Columbia, University of Wisconsin-Madison, Brookhaven National Laboratory, Los Alamos National Laboratory, Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea, Department of Physics, Oregon State University, Corvallis, OR 97331-6507, Imago Scientific Instruments Corp., Department of Physics, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6 Canada, Linfield College, PNNL, University of Washington, University of Victoria, IUPUI1, Wabash, IUPUI2, Environmental Biotechnology Institute, University of Idaho, Moscow ID 83843, Physics Department, University of Idaho, Moscow ID 83843, Environmental Biotechnology Institute, University of Idaho, Moscow, ID 83844, Physics Department, University of Idaho, Moscow, Idaho 83844, TRIUMF / UBC, 5CSNSM-IN2P3-CNRS, Universit\&#039;e Paris 11, University of Manitoba, Texas A\&M, U. Manitoba, Tel Aviv U., U. British Columbia, Universidad de Pa\&#039;is Vasco, Department of Physics, University of Idaho, Moscow, Idaho 83844-0903, University of Idaho, Boise State University, Idaho State University, NASA Ames Research Center