Fluorescence and UV-vis Spectroscopy of Synovial Fluids

POSTER

Abstract

Total joint arthroplasty involves replacing the worn cartilaginous surfaces of the joint with man-made materials that are designed to be biocompatible and to withstand mechanical stresses. Commonly these bearing materials consist of metallic alloys (TiAlV or CoCrMo) and UHMWPE. Following joint arthroplasty, the normal generation of micro-metallic wear debris particles that dislodge from the prosthesis has been shown to cause inflammatory aseptic osteolysis (bone loss) that ultimately results in the failure of the implant. Here we report our results on the novel use of Fluorescence and UV-vis spectroscopy to investigate the metallic content of synovial fluid specimens taken from postoperative total knee arthroplasties. Preliminary finding showed presence of alumina and chromium is some specimens. The ability to detect and monitor the wear rate of these implants could have far reaching implications in the prevention of metallic wear-debris induced osteolysis and impending implant failure.

Authors

  • Kurt Wiesenfeld

    Miami University, Summa Health System, Akron, John Carroll University, Prof, Dr, BfS, Germany, Florida State University, Monmouth College, Ohio Wesleyan University, Kenyon College, University of Cincinnati, Brookhaven National Lab, University of Wisconsin Oshkosh, Dept. of Chermical Engineering, Carnegie Mellon University, Cleveland State University, The Neurological Institute, Epilepsy Center, Department of Neurology, Cleveland Clinic, Un. of Stockholm, The University of Akron, Case Western Reserve University, West Virginia University, Kalamazoo College and Editor, American Journal of Physics, Denison University, University of Southern Florida, Johannes-Gutenberg-Universitat, BfS (Germany), Shanghai Jiao Tong University, Department of Physics, West Virginia University, Kansas State University, The Pennsylvania State University, University of Wisconsin-Oshkosh, Purdue University, Saint Jospeh's College, University of Washington, Indiana University, University of Potsdam, Georgia Institute of Technology

  • Nenad Stojilovic

    University of Wisconsin Oshkosh

  • Kurt Wiesenfeld

    Miami University, Summa Health System, Akron, John Carroll University, Prof, Dr, BfS, Germany, Florida State University, Monmouth College, Ohio Wesleyan University, Kenyon College, University of Cincinnati, Brookhaven National Lab, University of Wisconsin Oshkosh, Dept. of Chermical Engineering, Carnegie Mellon University, Cleveland State University, The Neurological Institute, Epilepsy Center, Department of Neurology, Cleveland Clinic, Un. of Stockholm, The University of Akron, Case Western Reserve University, West Virginia University, Kalamazoo College and Editor, American Journal of Physics, Denison University, University of Southern Florida, Johannes-Gutenberg-Universitat, BfS (Germany), Shanghai Jiao Tong University, Department of Physics, West Virginia University, Kansas State University, The Pennsylvania State University, University of Wisconsin-Oshkosh, Purdue University, Saint Jospeh's College, University of Washington, Indiana University, University of Potsdam, Georgia Institute of Technology