Copy number variation and mutation

POSTER

Abstract

Until very recently, the standard model of DNA included two genes for each trait. This dated model has given way to a model that includes copies of some genes well in excess of the canonical two. Copy number variations in the human genome play critical roles in causing or aggravating a number of syndromes and diseases while providing increased resistance to others. We explore the role of mutation, crossover, inversion, and reproduction in determining copy number variations in a numerical simulation of a population. The numerical model consists of a population of individuals, where each individual is represented by a single strand of DNA with the same number of genes. Each gene is initially assigned to one of two traits. Fitness of the individual is determined by the two most fit genes for trait one, and trait two genetic material is treated as a reservoir of junk DNA. After a sufficient number of generations, during which the genetic distribution is allowed to reach a steady-state, the mean numberof genes per trait and the copy number variation are recorded. Here, we focus on the role of mutation and compare simulation results to theory.

Authors

  • Brian Clark

    Illinois State University

  • Michael Turner

    Illinois Institute of Technology, Bettendorf High School, Bettendorf, IA, Mississippi Bend Area Education Agency, Bettendorf, IA, Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, New York 11973, USA, Ames Laboratory and Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA, Max-Planck-Institut fuer Mikrostrukturphysik, Halle, Germany, CNRS, Universite Lyon I, France, Freie Universitaet Berlin, Germany, University of Jyvaskila, Finaland, Iowa State University/Ames Laboratory, Materials Science Division, Argonne National Laboratory and Department of Chemistry, Northwestern University, Materials Science Division, Argonne National Laboratory, Advanced Photon Source, Argonne National Laboratory, Ames Laboratory and Iowa State University, Indiana University, Illinois State University, University of Iowa, Louisiana State University, University of Warwick, Rutherford Appleton Laboratory, Coe College, University of Northern Iowa, Iowa State University and Ames Laboratory, University of Illinois, Ames Laboratory, University of Florida, Tulane University, The Department of Physics and The James Franck Institute, The University of Chicago, J.R. Macdonald Laboratory, Department of Physics, Kansas State University, Manhattan, KS 66506, Department of Physics, Augustana College, Sioux Falls, SD 57197, Intense Laser Physics Theory Unit, Illinois State University, Argonne National Laboratory, Dr, Drake University, Physics Department, Ocean University of China, Qingdao, Physics Department, Southern Illinois University Carbondale, Ames Laboratory and Department of Physics and Astronomy, Iowa State University, Ames, Iowa 50011, Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, USA, Department of Physics, The University of Texas at Austin, Austin, Texas 78712, USA, NEST-CNR-INFM and Scuola Normale Superiore, I-56126 Pisa, Italy, University of New Hampshire Department of Physics, University of Chicago

  • Michael Turner

    Illinois Institute of Technology, Bettendorf High School, Bettendorf, IA, Mississippi Bend Area Education Agency, Bettendorf, IA, Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, New York 11973, USA, Ames Laboratory and Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA, Max-Planck-Institut fuer Mikrostrukturphysik, Halle, Germany, CNRS, Universite Lyon I, France, Freie Universitaet Berlin, Germany, University of Jyvaskila, Finaland, Iowa State University/Ames Laboratory, Materials Science Division, Argonne National Laboratory and Department of Chemistry, Northwestern University, Materials Science Division, Argonne National Laboratory, Advanced Photon Source, Argonne National Laboratory, Ames Laboratory and Iowa State University, Indiana University, Illinois State University, University of Iowa, Louisiana State University, University of Warwick, Rutherford Appleton Laboratory, Coe College, University of Northern Iowa, Iowa State University and Ames Laboratory, University of Illinois, Ames Laboratory, University of Florida, Tulane University, The Department of Physics and The James Franck Institute, The University of Chicago, J.R. Macdonald Laboratory, Department of Physics, Kansas State University, Manhattan, KS 66506, Department of Physics, Augustana College, Sioux Falls, SD 57197, Intense Laser Physics Theory Unit, Illinois State University, Argonne National Laboratory, Dr, Drake University, Physics Department, Ocean University of China, Qingdao, Physics Department, Southern Illinois University Carbondale, Ames Laboratory and Department of Physics and Astronomy, Iowa State University, Ames, Iowa 50011, Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, USA, Department of Physics, The University of Texas at Austin, Austin, Texas 78712, USA, NEST-CNR-INFM and Scuola Normale Superiore, I-56126 Pisa, Italy, University of New Hampshire Department of Physics, University of Chicago