Cholesterol Partitioning in Unilamellar Vesicles determined by Small Angle X-ray Scattering

POSTER

Abstract

Liposomes are artificial vesicles that are used for drug encapsulation and administration of pharmaceuticals or cellular nutrients. In this paper, small-angle x-ray scattering(SAXS) was used to study the structural properties of small unilamellar vesicles (SUV). In particular, we studied liposomes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol bilayer. We examined the location of cholesterol by labelling cholesterol with bromine molecule. Lipid bilayer’s electron density profile has been modeled using a series of Gaussian shells and we reveal asymmetry within inner and outer lipid bilayer’s leaflet and that cholesterol is located one side of the leaflet adjusting itself to the curvature of a liposome.

Authors

  • Preeti Vodnala

    Northern Illinois University

  • Swapan Chattopadhyay

    Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, Northern Illinois University and Argonne National Laboratory, Northern Illinois University, None, Monmouth College, IL, University of California Santa Cruz, Southern Illinois University Carbondale, Argonne National Laboratory, University of Iowa, Sinop University, Bingol University, Univ of Northern Iowa, University of California, Riverside, University of Northern Iowa, University of Wisconsin, Fairfield University, North Central College

  • Swapan Chattopadhyay

    Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, Northern Illinois University and Argonne National Laboratory, Northern Illinois University, None, Monmouth College, IL, University of California Santa Cruz, Southern Illinois University Carbondale, Argonne National Laboratory, University of Iowa, Sinop University, Bingol University, Univ of Northern Iowa, University of California, Riverside, University of Northern Iowa, University of Wisconsin, Fairfield University, North Central College

  • Swapan Chattopadhyay

    Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, Northern Illinois University and Argonne National Laboratory, Northern Illinois University, None, Monmouth College, IL, University of California Santa Cruz, Southern Illinois University Carbondale, Argonne National Laboratory, University of Iowa, Sinop University, Bingol University, Univ of Northern Iowa, University of California, Riverside, University of Northern Iowa, University of Wisconsin, Fairfield University, North Central College

  • Swapan Chattopadhyay

    Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, Northern Illinois University and Argonne National Laboratory, Northern Illinois University, None, Monmouth College, IL, University of California Santa Cruz, Southern Illinois University Carbondale, Argonne National Laboratory, University of Iowa, Sinop University, Bingol University, Univ of Northern Iowa, University of California, Riverside, University of Northern Iowa, University of Wisconsin, Fairfield University, North Central College

  • Swapan Chattopadhyay

    Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, Northern Illinois University and Argonne National Laboratory, Northern Illinois University, None, Monmouth College, IL, University of California Santa Cruz, Southern Illinois University Carbondale, Argonne National Laboratory, University of Iowa, Sinop University, Bingol University, Univ of Northern Iowa, University of California, Riverside, University of Northern Iowa, University of Wisconsin, Fairfield University, North Central College