Stochastic lattice simulation of competing nucleoproteins binding to single-stranded DNA

Homologous recombination (HR) is one of the most enigmatic processes in DNA metabolism and is a fundamental driver of evolution. Its central step involves the search for homology between two DNA molecules and the subsequent exchange of the DNA strands. We developed a dynamic Monte Carlo model to study the competition and dynamics of nucleoproteins binding/unbinding to single stranded DNA. In addition, we have developed a computational toolbox to identify and categorize different kinetic scenarios from single-molecule data.