Search for New Physics with Flavor

In recent years, the quark-mixing angles and the $CP$ phase in the Cabibbo-Kobayashi-Maskawa matrix have been measured with very high precision. Today, the availability of high-luminosity hadronic and electron-positron accelerators enables indirect searches for new quark generations and interactions at energies in the TeV range via rare processes involving quantum-loops. Low energy constraints for beyond Standard Model scenarios are derived from such measurements. Recent experimental results of searches in reactions involving $b$, $c$, and $s$-quarks will be presented.