Novel exchange-coupled core/shell nanoparticles for advanced magnetic hyperthermia

ORAL

Abstract

Of any disease, probably the most well-known is cancer, and while there are treatments available, a new form of treatment is needed that is safer for the patient. Studies on magnetic nanoparticles (MNPs) have shown their promise in biomedical applications, such as magnetic hyperthermia, which employs MNPs for localized destructive heating of cancer cells. It has been found that as the size of the MNP decreases, the heating efficiency drastically decreases. Recently, however, a large improvement in heating efficiency has been reported in exchange-coupling of MNPs between a soft and a hard magnetic material. In this study, we optimized the heating efficiency of exchange-coupled MNPs composed of a soft magnetic core (Fe$_{\mathrm{3}}$O$_{\mathrm{4}})$ and a hard magnetic shell (CoFe$_{\mathrm{2}}$O$_{\mathrm{4}})$ by tuning both the shape of the nanoparticles and their concentration in solution. The MNPs show high magnetization (\textasciitilde 80 emu/g) and superparamagnetic-like behavior at room temperature. We compare the specific absorption rate (SAR) for each set of MNPs and correlate the results to shape distribution and concentration in solution. This study shows that exchange-coupled MNPs for magnetic hyperthermia are promising as route for non-harmful cancer treatment. A new approach for controlling the inductive heat for cancer treatment using a mixture of spheres and cubes is proposed.

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Authors

  • Caroline Collins

    Bob Jones University

  • S.S. Gupta

    Department of Applied Mathematics & Sciences, Khalifa University, Abu Dhabi 127788, UAE, Physics Department, Kalamazoo College, Kalamazoo, Michigan 49006, USA, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, USA, Indian Institute of Technology Ropar, Nangal Road, Rupnagar (Ropar), Punjab 140 001, India, The Institute for Nuclear Research, Moscow, Davidson Coll, Western kentucky University, Bowling Green, KY 42101, Naval Postgraduate School, Austin Peay State University, Univ of Tennessee, Knoxville, University of Nebraska, Rajarata University of Sri Lanka, University of West Georgia, Department of Physics, University of Alabama at Birmingham, Center for High Pressure Science and Technology Advanced Research, Northwestern Univ, Univ of Virginia, Western Kentucky University, Physics Dept. Bowling Green, KY, Department of Physics, The University of Texas-Rio Grande Valley, TX 78539, Western Kentucky University, Bowling Green, KY 42101, Western Kentucky University, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom, Austin Peay State Univ, University of Pardubice, Clemson University, Appalachian State Univ, Department of Physics, University of West Georgia, Department of Geosciences, University of West Georgia, Department of Physics and Astronomy, Georgia State University, Francis Marion University, The Pennsylvania State University, Auburn University, Department of Physics & Astronomy, Louisiana State University, Baton Rouge, Louisiana, Department of Physics, Brigham Young University-Idaho, Rexburg, Idaho, Department of Physics,North Carolina State University, William Mong Institute of Nano Science and Technology, MSTD, Oak Ridge National Laboratory, Department of Physics and Astronomy, Vanderbilt University, Univ of Bristol, University of Alabama in Birmingham, Georgia Institute of Technology, Sandia National Laboratories, University of South Florida

  • S.S. Gupta

    Department of Applied Mathematics & Sciences, Khalifa University, Abu Dhabi 127788, UAE, Physics Department, Kalamazoo College, Kalamazoo, Michigan 49006, USA, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, USA, Indian Institute of Technology Ropar, Nangal Road, Rupnagar (Ropar), Punjab 140 001, India, The Institute for Nuclear Research, Moscow, Davidson Coll, Western kentucky University, Bowling Green, KY 42101, Naval Postgraduate School, Austin Peay State University, Univ of Tennessee, Knoxville, University of Nebraska, Rajarata University of Sri Lanka, University of West Georgia, Department of Physics, University of Alabama at Birmingham, Center for High Pressure Science and Technology Advanced Research, Northwestern Univ, Univ of Virginia, Western Kentucky University, Physics Dept. Bowling Green, KY, Department of Physics, The University of Texas-Rio Grande Valley, TX 78539, Western Kentucky University, Bowling Green, KY 42101, Western Kentucky University, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom, Austin Peay State Univ, University of Pardubice, Clemson University, Appalachian State Univ, Department of Physics, University of West Georgia, Department of Geosciences, University of West Georgia, Department of Physics and Astronomy, Georgia State University, Francis Marion University, The Pennsylvania State University, Auburn University, Department of Physics & Astronomy, Louisiana State University, Baton Rouge, Louisiana, Department of Physics, Brigham Young University-Idaho, Rexburg, Idaho, Department of Physics,North Carolina State University, William Mong Institute of Nano Science and Technology, MSTD, Oak Ridge National Laboratory, Department of Physics and Astronomy, Vanderbilt University, Univ of Bristol, University of Alabama in Birmingham, Georgia Institute of Technology, Sandia National Laboratories, University of South Florida

  • S.S. Gupta

    Department of Applied Mathematics & Sciences, Khalifa University, Abu Dhabi 127788, UAE, Physics Department, Kalamazoo College, Kalamazoo, Michigan 49006, USA, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, USA, Indian Institute of Technology Ropar, Nangal Road, Rupnagar (Ropar), Punjab 140 001, India, The Institute for Nuclear Research, Moscow, Davidson Coll, Western kentucky University, Bowling Green, KY 42101, Naval Postgraduate School, Austin Peay State University, Univ of Tennessee, Knoxville, University of Nebraska, Rajarata University of Sri Lanka, University of West Georgia, Department of Physics, University of Alabama at Birmingham, Center for High Pressure Science and Technology Advanced Research, Northwestern Univ, Univ of Virginia, Western Kentucky University, Physics Dept. Bowling Green, KY, Department of Physics, The University of Texas-Rio Grande Valley, TX 78539, Western Kentucky University, Bowling Green, KY 42101, Western Kentucky University, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom, Austin Peay State Univ, University of Pardubice, Clemson University, Appalachian State Univ, Department of Physics, University of West Georgia, Department of Geosciences, University of West Georgia, Department of Physics and Astronomy, Georgia State University, Francis Marion University, The Pennsylvania State University, Auburn University, Department of Physics & Astronomy, Louisiana State University, Baton Rouge, Louisiana, Department of Physics, Brigham Young University-Idaho, Rexburg, Idaho, Department of Physics,North Carolina State University, William Mong Institute of Nano Science and Technology, MSTD, Oak Ridge National Laboratory, Department of Physics and Astronomy, Vanderbilt University, Univ of Bristol, University of Alabama in Birmingham, Georgia Institute of Technology, Sandia National Laboratories, University of South Florida

  • S.S. Gupta

    Department of Applied Mathematics & Sciences, Khalifa University, Abu Dhabi 127788, UAE, Physics Department, Kalamazoo College, Kalamazoo, Michigan 49006, USA, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, USA, Indian Institute of Technology Ropar, Nangal Road, Rupnagar (Ropar), Punjab 140 001, India, The Institute for Nuclear Research, Moscow, Davidson Coll, Western kentucky University, Bowling Green, KY 42101, Naval Postgraduate School, Austin Peay State University, Univ of Tennessee, Knoxville, University of Nebraska, Rajarata University of Sri Lanka, University of West Georgia, Department of Physics, University of Alabama at Birmingham, Center for High Pressure Science and Technology Advanced Research, Northwestern Univ, Univ of Virginia, Western Kentucky University, Physics Dept. Bowling Green, KY, Department of Physics, The University of Texas-Rio Grande Valley, TX 78539, Western Kentucky University, Bowling Green, KY 42101, Western Kentucky University, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom, Austin Peay State Univ, University of Pardubice, Clemson University, Appalachian State Univ, Department of Physics, University of West Georgia, Department of Geosciences, University of West Georgia, Department of Physics and Astronomy, Georgia State University, Francis Marion University, The Pennsylvania State University, Auburn University, Department of Physics & Astronomy, Louisiana State University, Baton Rouge, Louisiana, Department of Physics, Brigham Young University-Idaho, Rexburg, Idaho, Department of Physics,North Carolina State University, William Mong Institute of Nano Science and Technology, MSTD, Oak Ridge National Laboratory, Department of Physics and Astronomy, Vanderbilt University, Univ of Bristol, University of Alabama in Birmingham, Georgia Institute of Technology, Sandia National Laboratories, University of South Florida