Invited Talk Rohit PappuComplex coacervation and charge regulation of intrinsically disordered proteins
ORAL · Invited
Abstract
Thiis talk will focus on the impact of asymmetric complex coacervation as an organizer of the nucleolus, the setting up of interphase electrochemical gradients, and the emerging physics of charge regulation of highly charged intrinscially disordered proteins
*Air Force Office of Scientific Research, National Science Foundation, and St. Jude Children's Research Hospital
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Publication: M.R. King, K.M. Ruff, A.Z. Lin, A. Pant, J.M. Lalmansingh, T. Wu, M. Farag, W. Ouyang, M.J. Fossat, E. Lundberg, M.D. Lew, M.D. Vahey, R.V. Pappu. (2024). Macromolecular condensation organizes nucleolar sub-phases and sets up a pH gradient. Cell, 187: 1889-1906.E24.
A. E. Posey§, A. Bremer§, N. A. Erkamp§, A. Pant, Y. Dai, T. Mittag*, R.V. Pappu*. (§Equal contributions; *Co-corresponding authors). (2024). Biomolecular condensates are characterized by interphase electric potentials. Journal of the American Chemical Society. 146: 28268-28281.
Presenters
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Rohit V Pappu
- Washington University, St. Louis