Theory of Dynamics of Intrinsically Disordered Proteins in Biomolecular Condensates

ORAL

Abstract

We will present a general theory of dynamics of intrinsically disordered proteins (IDPs) in biomolecular condensates, by accounting for their sequence, charge decoration, and van der Waals interaction, and self-consistently treating the coupling among conformational entropy of IDPs, electrostatics, and hydrodynamics. Predictions for biomolecular condensates of α-Synuclein will be illustrated.

*We thank the National Science Foundation (Grant No. DMR 2309539) and AFOSR (Grant No. FA9550-23-1-0584) for financial support.

–

Presenters

  • Murugappan Muthukumar

    • University of Massachusetts Amherst

Authors

  • Murugappan Muthukumar

    • University of Massachusetts Amherst