Probing the biomechanics of wound resilience in a giant single cell
ORAL · Invited
Abstract
Wound healing is an essential biological process for maintaining homeostasis and, ultimately, for survival. We investigate the mechanisms underlying extreme wound healing in Stentor coeruleus, a single-celled organism, capable of recovering from drastic membrane wounds exceeding half of the cell surface. This talk focuses on our recent efforts on developing a microfluidic platform for the manipulation and reproducible wounding of the cell, which enables the investigation of the biomechanics of wound closure, specifically the role of the cytoskeleton. Additionally, the microfluidics platform allows us to explore how the cell resists mechanical wounds. Together, these findings reveal new biophysical mechanisms underlying the cell's wound resilience.
*The work was supported by the National Science Foundation (NSF Award 2317442), and in part by the Center for Cellular Construction, which is a Science and Technology Center funded by the National Science Foundation (NSF Award: DBI-1548297). Device fabrication was performed in the Stanford Nano Shared Facilities (SNSF) and the Stanford Nanofabrication Facilities (SNF).
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Presenters
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Sindy K Tang,
- Stanford University