Mechanisms of virus budding through membranes

ORAL

Abstract

We investigate the dynamics of membrane budding from both a flat membrane and a vesicle, focusing on key factors that influence this process. By comparing budding in these two settings, we analyze energy changes using analytical and numerical methods. Our study examines the effects of surface tension, bending modulus, and spontaneous curvature on the budding process. Simulations reveal that budding from a flat membrane stall due to high stretching energy and energy barriers at the neck while budding from a vesicle proceeds successfully under the same conditions. This analysis enhances our understanding of how these physical properties affect budding efficiency, with implications for membrane-related phenomena such as viral budding and vesicle formation.

*S.Z. and R.Z. acknowledge support from NSF DMR-2131963 and the University of California Multicampus Research Programs and Initiatives (Grant No. M21PR3267).

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Presenters

  • Shuyang Zhang

    • University of California, Riverside

Authors

  • Shuyang Zhang

    • University of California, Riverside

  • Siyu Li

    • California State Polytechnic University

  • Ajay Gopinathan

    • University of California, Merced
    • Dept. of Physics, UC Merced
    • Department of Physics, University of California, Merced

  • Paul van der Schoot

    • Eindhoven University of Technology

  • Roya Zandi

    • University of California, Riverside