Toward ultimate precision in QCD calculations for the Large Hadron Collider

The upcoming high-luminosity runs at the Large Hadron Collider offer unique opportunities to study fundamental forces of nature via a combination of precision measurements and wide-ranging searches for new physics. Success at this precision frontier demands synergistic developments in multi-loop theoretical calculations, simulations of experimental detection, and analysis of nonperturbative parton distributions. The LHC also is a unique statistics lab thanks to introduction of novel AI/ML techniques in both experiment and theory. How does one strike a balance between precision and replicability in determinations of fundamental parameters in these complex mega-experiments? I review emergent cross-cutting strategies to achieve such precision through advancements in perturbative QCD calculations, global analyses of hadron structure, and multivariate statistics with AI/ML components.