Insufficiency of Known Physics to Explain Anomalous Intracellular Transport

Life would not be possible without selective transport of proteins to specific targets sites on DNA. Applying all known laws of physics and thermodynamics is insufficient to explain the specificity of the molecule-to-molecule match. This work provides proof that anomalously specific transport cannot be satisfactorily modeled using electromagnetic drift, dielectrophoresis, concentration-driven diffusion, bond-hopping surface transfer, pressure gradients or peristaltic movement, siphoning, centrifugal pseudoforce, or gravity. Using all known physics as of 2026, such anomalous intracellular delivery remains a significant unsolved mystery. The results presented herein therefore provide motivation for the discovery of a new mechanism of intracellular site identification. Based on the calculations presented here, the characteristics of this new force or pseudoforce are presented as specifications for such investigation.