Physics of Proteins III: Intrinsically Disordered Proteins & Protein Folding

Presentations

• Physics based machine learning decodes sequence-confirmation link in the disordered proteome

  ORAL

  March 17, 2026, 8:00 AM – March 17, 2026, 8:12 AM

  Publication: Houston L, Phillips M, Torres A, Gaalswyk K, Ghosh K. Physics-Based Machine Learning Trains Hamiltonians and Decodes the Sequence-Conformation Relation in the Disordered Proteome. J Chem Theory Comput. 2024 Nov 26;20(22):10266-10274. doi: 10.1021/acs.jctc.4c01114. Epub 2024 Nov 6. PMID: 39504303; PMCID: PMC12257546.

  Presenters

  • Lilianna Houston

    • University of Denver

  Authors

  • Lilianna Houston

    • University of Denver

  • Kingshuk Ghosh

    • University of Denver

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• Molecular Dynamics Simulations of Fibril Formation of Chiral Peptides

  ORAL

  March 17, 2026, 8:12 AM – March 17, 2026, 8:24 AM

  Presenters

  • Jianping Chen

    • New Jersey Institute of Technology

  Authors

  • Jianping Chen

    • New Jersey Institute of Technology

  • Cristiano L Dias

    • New Jersey Institute of Technology

  • Bradley Nilsson

    • University of Rochester

  • Chris Jones

    • University of Rochester

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• Abstract Withdrawn

  ORAL · Withdrawn

  March 17, 2026, 8:24 AM – March 17, 2026, 8:36 AM

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• Molecular mechanisms of small molecules that modulate the properties of biomolecular condensates

  ORAL · Invited

  March 17, 2026, 8:36 AM – March 17, 2026, 9:12 AM

  Publication: Molecular mechanisms of small molecules that stabilize oligomers of a phase separating disordered protein. J Zhu, TR Sisk, B Mateos, S Bielskute, X Salvatella, P Robustelli, biorxiv, 2025
  
  How does 1,6-hexanediol modulate the conformational ensembles of IDPs in solution and in condensates? KM Reid, P Robustelli, (under preparation)

  Presenters

  • Paul Robustelli

    • Dartmouth College

  Authors

  • Paul Robustelli

    • Dartmouth College

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• Microfluidic insights into the fibrillation of amyloids

  ORAL

  March 17, 2026, 9:12 AM – March 17, 2026, 9:24 AM

  Presenters

  • Gaëlle A Audéoud

    • University of Bordeaux

  Authors

  • Gaëlle A Audéoud

    • University of Bordeaux

  • Lucie Khemtemourian

    • Université de Bordeaux, CNRS

  • Yacine Amarouchene

    • Université de Bordeaux
    • Université de Bordeaux, CNRS

  • Marion Mathelié-Guinlet

    • Université de Bordeaux, CNRS

  • Thomas Salez

    • University of Bordeaux
    • University of Bordeaux, CNRS

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• Interaction Map Frameworks Reveal Sequence-Encoded Function and Complexation in Coevolved Disordered Proteins

  ORAL

  March 17, 2026, 9:24 AM – March 17, 2026, 9:36 AM

  Publication: Statistical Physics-Based Approaches to Model the Function and Complexation of Disordered Proteins
  
  Austin Haider, Kari Gaalswyk, Lilianna Houston, Nicholas J. Ose, S. Banu Ozkan, and Kingshuk Ghosh
  The Journal of Physical Chemistry B 2025 129 (40), 10285-10297
  DOI: 10.1021/acs.jpcb.5c05422

  Presenters

  • Austin J Haider

    • University of Denver

  Authors

  • Austin J Haider

    • University of Denver

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• Higher-Order Interactions and Water-Driven Fluctuations Affect Condensate Mechanics and Longevity

  ORAL

  March 17, 2026, 9:36 AM – March 17, 2026, 9:48 AM

  Presenters

  • Jingyuan Li

    • Zhejiang University

  Authors

  • Jingyuan Li

    • Zhejiang University

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• Fluorescence Resonance Energy Transfer Reveals β-Sheet–Dominant Structural Features in Extracellular Vesicles from Pancreatic Cancer Detection

  ORAL

  March 17, 2026, 9:48 AM – March 17, 2026, 10:00 AM

  Presenters

  • Alfred Akinlalu

    • University Of Denver
    • University of Denver

  Authors

  • Alfred Akinlalu

    • University Of Denver
    • University of Denver

  • Dali Sun

    • University of Denver

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• Spontaneous insertion of Aβ42 dimers but not monomers into a cholesterol-rich lipid bilayer

  ORAL

  March 17, 2026, 10:00 AM – March 17, 2026, 10:12 AM

  Presenters

  • Rachit Pandey

    • Drexel University

  Authors

  • Rachit Pandey

    • Drexel University

  • Brian Andrews

    • Drexel University

  • Brigita Urbanc

    • Drexel University

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• Integrating charge and non-charge patterning to predict Liquid-Liquid Phase Separation in IDPs

  ORAL

  March 17, 2026, 10:12 AM – March 17, 2026, 10:24 AM

  Presenters

  • Nicolas W Lamb

    • University of Denver

  Authors

  • Nicolas W Lamb

    • University of Denver

  • Michael Phillips

    • University of Denver

  • Lilianna Houston

    • University of Denver

  • Kingshuk Ghosh

    • University of Denver

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• Speed–Energy–Efficiency Trade-offs in the Hsp70 Folding Cycle

  ORAL

  March 17, 2026, 10:24 AM – March 17, 2026, 10:36 AM

  Publication: J. Phys. Chem. B 2024, 128, 49, 12101–12113 (2024)

  Presenters

  • Ajeet Kumar Sharma

    • Indian Institute of Technology, Jammu

  Authors

  • Ajeet Kumar Sharma

    • Indian Institute of Technology, Jammu

  • Rupal Chauhan

    • Indian Institute of Technology, Jammu

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• Colloidal stabilization of proteins via weak adsorption of amino acids onto surface patches

  ORAL

  March 17, 2026, 10:36 AM – March 17, 2026, 10:48 AM

  Publication: T. Mao et al. Stabilizing effect of amino acids on protein and colloidal dispersions. Nature 645, 915–921 (2025). https://doi.org/10.1038/s41586-025-09506-w

  Presenters

  • Karim Al Zahabi

    • Massachusetts Institute of Technology

  Authors

  • Karim Al Zahabi

    • Massachusetts Institute of Technology

  • Alfredo Alexander-Katz

    • Massachusetts Institute of Technology

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• Sequence and Phosphorylation Modifications Dictate Charge Transport in Cell-Penetrating Peptides for Bioelectronic Applications

  ORAL

  March 17, 2026, 10:48 AM – March 17, 2026, 11:00 AM

  Publication: Plan to submit.. William Thompson, Ali Akbar Ashkarran, Charge Transport in Cell-Penetrating Peptides: Influence of Sequence Modification and Phosphorylation, Small, 2025.

  Presenters

  • Will Thompson

    • University of Colorado, Colorado Springs

  Authors

  • Will Thompson

    • University of Colorado, Colorado Springs

  • Aliakbar A Ashkarran

    • Department of Physics and Energy Science, University of Colorado Colorado Springs, Colorado Springs, CO, USA; BioFrontiers Center, University of Colorado Colorado Springs, CO
    • University of Colorado Colorado Springs
    • University of Colorado at Colorado Springs

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