Effects of Common Anesthetics on Lipid membrane Fluidity
Oral-In-person · Withdrawn
Abstract
In this study, the effects of anesthetic drugs propofol and sevoflurane on lipid membrane fluidity are compared with that of isoflurane. To get a basic picture, the simplest lipid membrane of DPPC was chosen. Lipid membranes were labeled with DPH-PC fluorescent probe, whose fluorescence anisotropy (r) showed an immediate decrease after adding the drugs, indicating a sharp increase of membrane fluidity. We studied clinical concentrations of 10 µM propofol, 0.5 mM sevoflurane and 1 mM isoflurane. The fluidity increases at these concentrations on DPPC lipid bilayer are comparable, and all drugs are quite effective to loosen up the highly ordered lipid domains of saturated lipids.
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Publication: Siddique MB, Nozohouri E, Ahn Y, Zoubi S, Bickel U, Huang J. A Comparative Study of Common Anesthetics Propofol, Sevoflurane, Isoflurane and Ketamine on Lipid Membrane Fluidity. Int J Mol Sci. 2025 Feb 5;26(3):1337. doi: 10.3390/ijms26031337. PMID: 39941104; PMCID: PMC11818908.
Presenters
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Muhammad Siddique
- Texas Tech University