Pyrvinium Pamoate's Effect on Models Lipid Membranes.

ORAL

Abstract

Pyrvinium pamoate (PP) is a compound that has garnered increasing attention as a potential anti-cancer drug. Recent clinical trials investigating the use of PP to treat pancreatic cancer have been launched. Additionally, PP has been approved by the FDA as a treatment for pinworm infestations.

We will present the first results on the effects of PP on biological membranes using neutron scattering techniques. As a model system, we utilized a simple 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) lipid bilayer with varying concentrations of cholesterol. We performed small-angle neutron scattering (SANS) and neutron spin echo (NSE) experiments. Our preliminary results suggest that while PP does not significantly alter the structure of the lipid bilayer, it does modify the mechanical properties of the membrane, with the effects varying depending on PP concentration. These findings provide the first molecular-level insights into the interactions between PP and lipid membranes.

*This research used resources at the High Flux Isotope Reactor and Spallation Neutron Source, DOE Office of Science User Facilities operated by the Oak Ridge National Laboratory. The beam time was allocated to SNS-NSE and Bio-SANS on proposal number IPTS-32397.This manuscript has been authored by UT-Battelle LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).

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Presenters

  • Piotr A Zolnierczuk

    • Oak Ridge National Laboratory

Authors

  • Piotr A Zolnierczuk

    • Oak Ridge National Laboratory

  • Shuo Qian

    • Oak Ridge National Laboratory

  • Wellington Leite

    • Oak Ridge National Laboratory

  • Gergely Nagy

    • Oak Ridge National Laboratory

  • Alexis Williams

    • Oak Ridge National Laboratory

  • Zuzanna Kulik

    • Gdansk Medical Universtity

  • Aleksandra Markiewicz

    • Gdansk Medical University