Pyrvinium Pamoate's Effect on Models Lipid Membranes.
Oral-In-person
Abstract
Pyrvinium pamoate (PP) is a compound that has garnered increasing attention as a potential anti-cancer drug. Recent clinical trials investigating the use of PP to treat pancreatic cancer have been launched. Additionally, PP has been approved by the FDA as a treatment for pinworm infestations.
We will present the first results on the effects of PP on biological membranes using neutron scattering techniques. As a model system, we utilized a simple 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) lipid bilayer with varying concentrations of cholesterol. We performed small-angle neutron scattering (SANS) and neutron spin echo (NSE) experiments. Our preliminary results suggest that while PP does not significantly alter the structure of the lipid bilayer, it does modify the mechanical properties of the membrane, with the effects varying depending on PP concentration. These findings provide the first molecular-level insights into the interactions between PP and lipid membranes.
We will present the first results on the effects of PP on biological membranes using neutron scattering techniques. As a model system, we utilized a simple 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) lipid bilayer with varying concentrations of cholesterol. We performed small-angle neutron scattering (SANS) and neutron spin echo (NSE) experiments. Our preliminary results suggest that while PP does not significantly alter the structure of the lipid bilayer, it does modify the mechanical properties of the membrane, with the effects varying depending on PP concentration. These findings provide the first molecular-level insights into the interactions between PP and lipid membranes.
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Presenters
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Piotr Zolnierczuk
- Oak Ridge National Laboratory