Soft-Lubrication Drainage and Rupture Limits in Particle-Driven Vesicles
Oral-In-person · Withdrawn
Abstract
The deformation and rupture of a lipid vesicle due to the forced normal approach of an inclusion
are essential to optimizing the design of magnetic giant unilamellar vesicles [magGUVs, Malik et al.,
Nanoscale 17, 13720 (2025)], with implications for active colloid-membrane interactions and cellular-
scale chemical delivery. Here, we investigate vesicles propelled by a force-driven rigid inclusion and
reveal a robust elastohydrodynamic mechanism: the inclusion outpaces the vesicle, sustaining a
thinning film that drains symmetrically and self-similarly, largely independent of initial shape. For
soft membranes and small inclusions, coupling drives a monotonic tension increase that can exceed
the lysis tension. Evaluating the maximal tension over a delivery distance, we map an operating
window in vesicle reduced area and size relative to the inclusion.
are essential to optimizing the design of magnetic giant unilamellar vesicles [magGUVs, Malik et al.,
Nanoscale 17, 13720 (2025)], with implications for active colloid-membrane interactions and cellular-
scale chemical delivery. Here, we investigate vesicles propelled by a force-driven rigid inclusion and
reveal a robust elastohydrodynamic mechanism: the inclusion outpaces the vesicle, sustaining a
thinning film that drains symmetrically and self-similarly, largely independent of initial shape. For
soft membranes and small inclusions, coupling drives a monotonic tension increase that can exceed
the lysis tension. Evaluating the maximal tension over a delivery distance, we map an operating
window in vesicle reduced area and size relative to the inclusion.
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Presenters
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Bryan Quaife
- Florida State University