Multiscale Dual-Field Control of Crystalline DNA Frameworks

External fields offer powerful routes to dynamically program organization at the colloidal and macroscale scales, but incorporating nanoscale structural control remains challenging. Here, we demonstrate a dual acoustic-magnetic field platform for assembling and steering DNA framework lattices with different crystallographic symmetries. We investigated the assembly of micron-sized framework crystals anchored onto magnetic beads and aligned them into extended string-like mesoscale and macroscale morphologies using standing acoustic waves. The formed structures persist for extended periods after field removal, maintaining their DNA-encoded nanoscale order and mesoscale morphology, as confirmed by small-angle X-ray scattering and optical microscopy, respectively. Thermal experiments revealed that the stability of the resulting morphologies depends on the underlying lattice symmetry, indicating a coupling between nanoscale organization and a mesoscale field-directed assembly. By subsequently applying magnetic fields, we explored steering, reorientation, and translation of these string morphologies, enabling post-assembly manipulation over their spatial configuration. The developed approach establishes a versatile framework for creating reconfigurable and nano-ordered materials, which can be structurally programmed from nanoscale, through DNA-directed interactions, to macroscale, through acoustic and magnetic fields.