Black Phosphorene-Enhanced Raman Scattering for Sensitive Detection of DNA Nucleotides

ORAL

Abstract

Abstract: The detection improvement of DNA nucleotides is essential for developing advanced bio-sensory devices. In the present work, we report using 2D Materials-Enhanced Raman spectroscopy (2D MERS) of DNA nucleotides. We show that Black phosphorene (BP) enhanced the Raman signal of DNA Nucleotides better than Graphene (Gr) and MoS2. This could be explained by the charge transfer that is more significant between Black Phosphorene and molecules compared to Gr and MoS2. Also, BP's anisotropy contributes to increasing molecules' dipole moment when positioned on its surface. This unique property of BP enhances its interaction with the molecules, thereby improving the detection sensitivity of DNA nucleotides. This study highlights the potential of BP as a promising platform for biosensor applications, paving the way for advances in biomolecular sensing.
Keywords: 2DMERS, Black phosphorene, Graphene, DNA nucleotides, charge transfer, anisotropy.

*OCP Foundation has supported this work with the project Grant AS70, "Towards phosphorene-based materials and devices, and with the support of the Chair 'Multiphysics and HPC led by Abdelouahad El Fatimy at the Mohammed VI Polytechnic University.

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Publication: 1. Bianca Adiaconita, Eugen Chiriac, Tiberiu Burinaru, Catalin Marculescu , Cristina Pachiu , Oana Brincoveanu, Octavian Simionescu and Marioara Avram. Biomolecules 2025, 15, 619
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Presenters

  • Ferdinand Nouaye

    • Mohammed VI Polytechnic University

Authors

  • Ferdinand Nouaye

    • Mohammed VI Polytechnic University