DNA Mechanics and Gene Expression
FOCUS · MAR-U58 · ID: 3979594
Presentations
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Free Energy Spectroscopy, a new method for investigating chromatin compaction.
ORAL · Invited
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Publication: Bonin K, Wang Y, Riveros I, Chen RW, Zhang B, Bundschuh R, Castro CE, Poirier MG. Free energy spectroscopy reveals the mechanistic landscape of chromatin compaction. bioRxiv [Preprint]. 2025 Aug 13:2025.08.13.670082. doi: 10.1101/2025.08.13.670082.
Presenters
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Michael G Poirier
- Ohio State University
Authors
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Michael G Poirier
- Ohio State University
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Geometry of Braided DNA Dictates Supercoiling Partition
ORAL
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Publication: Y. Hong, S. H. Park, H. Wang, M. D. Wang, "Geometry of Braided DNA Dictates Supercoiling Partition", bioRxiv (2024)
https://doi.org/10.1101/2024.10.08.617221Presenters
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Hanjie Wang
- Cornell University
Authors
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Yifeng Hong
- Cornell University
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Seong ha Park
- Janelia Research Campus
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Hanjie Wang
- Cornell University
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Michelle Wang
- Cornell University
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Mechanically heterogeneous DNA oligo-Catenanes
ORAL
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Presenters
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Terpsichori Alexiou
- University of Vienna
Authors
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Terpsichori Alexiou
- University of Vienna
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Christos Likos
- University of Vienna
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DNA in Tight Spaces
ORAL · Invited
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Publication: J. Yoo and A. Aksimentiev. The structure and intermolecular forces of DNA condensates. Nucleic Acids Research 44:2036-2046 (2016).
J. Yoo, H. Kim, A. Aksimentiev and T. Ha. Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation. Nature Communications 7:11045 (2016).
Jejoong Yoo, Sangwoo Park, Christopher Maffeo, Taekjip Ha, and Aleksei Aksimentiev. DNA Sequence and Methylation Prescribe the Inside-Out Conformational Dynamics and Bending Energetics of DNA Minicircles. Nucleic Acids Research 49, 11459–11475 (2021).
Kush Coshic, Christopher Maffeo, David Winogradoff, Aleksei Aksimentiev. The structure and physical properties of a packaged bacteriophage particle. Nature 627: 905–914 (2024).Presenters
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Aleksei Aksimentiev
- University of Illinois at Urbana-Champaign
- Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA
Authors
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Aleksei Aksimentiev
- University of Illinois at Urbana-Champaign
- Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA
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Investigating the Role of Cosmic Radiation in the Emergence of Biological Homochirality
ORAL
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Presenters
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Daniel Almonte
- Stony Brook University
Authors
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Daniel Almonte
- Stony Brook University
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Roger Blandford
- Stanford University
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Noemie Globus
- Instituto de Astronomía, UNAM, Ensenada, Baja California
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When many noisy genes optimize information flow
ORAL
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Presenters
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Nicholas Lawson
- Harvard University
Authors
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Nicholas Lawson
- Harvard University
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William S Bialek
- Princeton University
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Dynamical Phase Transitions in Models of Stochastic Gene Expression Conditioned on Large Deviations
ORAL
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Presenters
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Kenny Wong
- Department of Physics, The Ohio State University
Authors
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Kenny Wong
- Department of Physics, The Ohio State University
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Sho Inaba
- Department of Physics, Universtiy of Massachusetts Boston
- University of Massachusetts Boston
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Rahul V Kulkarni
- Department of Physics, University of Massachusetts Boston
- University of Massachusetts Boston
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Modeling Gene Expression with Time-Varying Transcription Rates
ORAL
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Presenters
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Amara McCune
- New York University
Authors
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Amara McCune
- New York University
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Sarah Kostinski
- New York University (NYU)
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Shlomi Reuveni
- Tel Aviv University
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Ido Golding
- University of Illinois at Urbana-Champaign
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Integrating Single-Cell Experiments and Stochastic Models to Understand and Predict Glucocorticoid Receptor Transport and DUSP1 mRNA Expression Dynamics
ORAL
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Publication: "Integrating Single-Cell Experiments and Stochastic Models to Understand and Predict Glucocorticoid Receptor Transport and DUSP1 mRNA Expression Dynamics" (planned)
Presenters
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Eric Ron
- Colorado State University
Authors
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Eric Ron
- Colorado State University
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Alex Popinga
- Colorado State University
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Jack Forman
- Colorado State University
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Luis Aguilera
- University of Colorado Anschutz
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Linda S Forero Quintero
- N/A
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Brian E Munsky
- Colorado State University
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Regulation of pericentromeric repeat copy number by EMT factors
ORAL
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Publication: Ghimire P, Motamedi M, Joh R (2024) Mathematical model for the role of multiple pericentromeric repeats on heterochromatin assembly. PLoS Comput Biol 20(4): e101202.
Ghimire P, Joh R (2025) Modeling the copy number of HSATII repeats in human pericentromere. Int J Mol Sci 26(10): 4751.Presenters
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Richard Joh
- Virginia Commonwealth University
Authors
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Richard Joh
- Virginia Commonwealth University
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Puranjan Ghimire
- Vigninia Commonwealth University
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Mo Motamedi
- Massachusetts General Hospital
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