From Microbes to Machines: Harnessing the multiscale organization of microbial communities for energy-efficient natural computing.
Oral-In-person · Withdrawn
Abstract
This talk explores the potential of microbial communities to transform energy-efficient computing by serving as analog platforms for solving complex computational problems. We consider a range of modelling approaches to capture the spatio-temporal behavior of microbial communities and view microbial communities as a reservoir computing platform. By leveraging multiscale insights and the intrinsic capabilities of these systems, we aim to uncover innovative strategies for sustainable, bio-inspired computing and deepen our understanding of nature’s mechanisms for efficient information processing in energy-limited environments.
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Publication: Johnson, C. G. M., Johnson, Z., Mackey, L. S. et al. Multi-Omics Reveals Temporal Scales of Carbon Metabolism in Synechococcus Elongatus PCC 7942 Under Light Disturbance. PRX Life, 3, (2025). https://doi.org/10.1103/l2dp-kw2t
Palmer, B.J., Almgren, A.S., Johnson, C.G.M. et al. BMX: Biological modelling and interface exchange. Sci Rep 13, 12235 (2023). https://doi.org/10.1038/s41598-023-39150-1
Bohm Agostini, N., Johnson, C., Cannon, W., and Tumeo, A. ChemComp: A Compilation Framework for Computing with Chemical Reaction Networks. In Proceedings of the 30th Asia and South Pacific Design Automation Conference (ASPDAC '25), (2025). https://doi.org/10.1145/3658617.3703315
Johnson, C. G. M., Fletcher, A. G., Soyer, O. S. ChemChaste: Simulating spatially inhomogeneous biochemical reaction–diffusion systems for modeling cell–environment feedbacks, GigaScience, 11, (2022). https://doi.org/10.1093/gigascience/giac051
Johnson, C. G. M., Bohm Agostini, N., Cannon, W. R., Tumeo, A. Computing with a Chemical Reservoir, 2024 IEEE International Conference on Rebooting Computing (ICRC), (2024). https://doi.org/10.1109/ICRC64395.2024.10937022
Palmer, B.J., Johnson, C.G.M., Almgren, A.S. et al. Three-dimensional modeling of hyphal fusion, branching, and nutrient transport in filamentous fungi. Phys. Rev. E, 112, (2025). https://doi.org/10.1103/xbjp-zqj1
Presenters
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Connah Johnson
- Pacific Northwest Natl Lab