Garfield Simulation of Beta Particle Detection Emitted from Radiolabeled Peritoneal Tumors

ORAL

Abstract

Secondary peritoneal carcinomatosis (PC) is one of the most lethal forms of cancer with little to no cure. Several different procedures (``Hot Chemo'' and cytoreductive surgery) have been attempted in various ways with not much success. The University of Texas at Arlington high energy physics (HEP) group has been developing a highly efficient, high resolution sensor using the Gas Electron Multiplier (GEM) technology. A synergistic fusion of HEP and medical physics is ongoing to target high confidence identification and location of PC tumors to significantly improve the survival rate of PC. With the use of Garfield, a computer program designed for detailed simulation of two and three dimensional drift chambers that was developed by CERN, we plan to duplicate beta particles emitted from tumor tissue loaded with fludeoxyglucose ($^{\mathrm{18}}$F-FDG) or copper-64 (radiolabeled biomarkers) that are then imaged by a small, triple GEM detector configuration setup. This simulation will lay a solid foundation for precise and accurate mapping of PC that enables physicians to target and eradicate it with minimally invasive procedures.

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Authors

  • Joshua Medford

    Univ of Texas, Arlington, University of Texas at Arlington

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University

  • Darren Depoy

    University of Michigan, Univeristy of Michigan, Texas A\&M University, UC Riverside, University of Massachusetts, STScI, NOAO, University of Texas, Cyclotron Institute, Texas A\&M University, ENEA, Italy, INFN, Italy, University of Texas at Austin, TX, Cyclotron Institute, TAMU, TX, Cyclotron Institute TAMU, TX, Cyclotron Institute - Texas A\&M University, Texas A\&M Univ, Texas A\&M University, Baylor University, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China, Department of Materials Science and Engineering, Texas A\&M University, College Station, Texas, Department of Mechanical Engineering, Texas A\&M University, College Station, Texas, Texas State University, University of Texas at Arlington, Lawrence Berkeley National Laboratory, DESY, Department of Physics and Astronomy, Texas A\&M University, Department of Physics, Syracuse University, Department of Physics and Astronomy, Vanderbilt University, Texas A\&M University, Princeton University and Baylor University, Texas A\&M Univ at Qatar, Kazan Federal University, Max Planck Institute for Nuclear Physics, Institue for Quantum Science and Engineering (IQSE) and Department of Physics \& Astronomy, Texas A\&M University, College Station, Texas 77843, USA, MIT, Sandia National Laboratories, Albuquerque, New Mexico, Postgrad, ORNL, Muons Inc., Texas Lutheran University, West Virginia University, Lawrence Livermore National Laboratory, University of Kentucky, US Naval Academy, University of Dallas, U.S. Naval Academy, Univ of Texas, Arlington, Department of Physics, Texas A\&M University, College Station, TX 77845, Science and Petroleum Departments, Texas A\&M University in Qatar, Doha, Qatar, Rice University, Houston, Texas, USA, Department of Physics, Texas State University, Florida A\&M University, Texas A\&M University in Qatar, Doha, Qatar, Physics and Astronomy Dept., TCU, Geology Dept., TCU, Colorado College, University of Texas at El Paso, University of Texas at Brownsville, Rochester Institute of Technology, Baylor University, Texas A\&M, Princeton University, Baylor University, Princeton University, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University; WPI-AIMR, Tohoku University, Japan, WPI-AIMR, Tohoku University, Department of Chemistry, Texas A\&M University, Materials Science and Engineering and Department of Physics and Astronomy, Texas A\&M University, WPI-AIMR, Tohoku University, Japan, Department of Physics and Astronomy, Texas A\&M University, College Station, Texas 77843, USA, Department of Physics and Astronomy, Texas A\&M University and WPI-Advanced Institute for Materials Research, Tohoku University, Japan, University of Texas at Austin, Center for Nonlinear Dynamics and Department of Physics, The University of Texas at Austin, JILA, NIST, Department of Physics and Astronomy, Texas A\&M University and Institute for Quantum Studies and Engineering, College Station, TX 77843-4242, USA, Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanov street, Nizhny Novgorod 603950, Russia, Department of Physics, University of Texas at Austin, Rice University, Texas A&M University