Raman Spectroscopy and Imaging of Red Blood Cells

ORAL

Abstract

Raman spectroscopy is a powerful spectroscopic technique that can be used for vibrational imaging of biological systems. We demonstrate Raman spectra and images of red blood cells (RBC) and ``ghost cells'' with hemoglobin removed and replaced with other molecules. We investigate the dependence on various experimental parameters such as different laser wavelengths and intensities. Our preliminarily results confirm the detection of hemoglobin in RBC and have a potential for future applications in nanoscale cell surface imaging.

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Authors

  • Ansam Talib

    • None

  • Sandra Bustamante

    • None

  • Zachary Liege

    • Baylor University, Texas A\&M University
    • None

  • Sarah Ritter

    • None

  • Alexzander Sinyukov

    • Texas A\&M University
    • None

  • Dmitri Voronine

    • Texas A\&M University, College Station, TX 77845
    • Texas A\&M University and Baylor University
    • None
    • Baylor University and Texas A\&M University
    • Texas A\&M University
    • Texas A\&M Univ

  • Alexei Sokolov

    • Texas A\&M University, Baylor University
    • Texas A\&M University and Baylor University
    • None
    • Baylor University, Texas A\&M University, and Princeton University
    • Texas A\&M University
    • Texas A\&M University, College Station, TX 77843, USA
    • Texas A&M University

  • Kenith Meissner

    • None

  • Marlan Scully

    • Texas A\&M University, Princeton University, Baylor University
    • Texas A\&M University, College Station, TX 77845
    • Texas A\&M University, Baylor University and Princeton University
    • None
    • professor
    • Baylor University, Texas A\&M University, and Princeton University
    • Texas A\&M University, College Station, TX 77843, USA; Princeton University, Princeton, NJ 08544, USA; Baylor University, Waco, TX 76798, USA
    • Texas A\&M University, Princeton, and Baylor University
    • Texas A\&M University
    • Texas A\&M Univ